KMID : 1059519920360050760
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Journal of the Korean Chemical Society 1992 Volume.36 No. 5 p.760 ~ p.763
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A Study on the Synthesis of New Medicinal Agents : Synthesis of 6-Thiocyanopenicillanic Acid Derivatives
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Lee Young-Haeng
Lee Chai-Ho Choi Won-Sik
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Abstract
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A new ¥â-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diazonium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(1a) with p-nitrobenzyl bromide, chloromethylpivalate and 1-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b¡d).
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