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KMID : 1059519920360050760
Journal of the Korean Chemical Society
1992 Volume.36 No. 5 p.760 ~ p.763
A Study on the Synthesis of New Medicinal Agents : Synthesis of 6-Thiocyanopenicillanic Acid Derivatives
Lee Young-Haeng

Lee Chai-Ho
Choi Won-Sik
Abstract
A new ¥â-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diazonium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(1a) with p-nitrobenzyl bromide, chloromethylpivalate and 1-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b¡­d).
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